Name: Macaroni and Cheese Stuffed Meatloaf Recipe
Prep time: 15 min
Cook time: 55 min
Total time: 1 h 10 min
Cuisine: American
Ingredients: 1 ¼ lb. lean ground beef; 1 cup Italian seasoned breadcrumbs; 2 large eggs; ½ cup finely diced onion; 2 tsp garlic powder; 2 tsp dried parsley; 1 tsp salt; 1 tsp black pepper; ½ cup honey BBQ sauce; 1 cup Bob Evans Macaroni and Cheese; 1 cup shredded mozzarella cheese; 1/3 cup ketchup; 2 tbsp brown sugar; 1 ½ tbsp yellow mustard

Jump to Recipe· 4.3 from 76 reviews

If you’re craving a comforting, crowd-pleasing dinner with a delightful twist, this Macaroni and Cheese Stuffed Meatloaf Recipe is an absolute game changer. Imagine a juicy, flavorful meatloaf packed full of creamy, cheesy macaroni right at its heart—each slice reveals a gooey, cheesy surprise that makes every bite unforgettable. Combining classic comfort food favorites into one hearty dish, this recipe brings warmth, richness, and a fun element of surprise to your table that everyone will love.

Ingredients You'll Need

The image shows a thick oval-shaped meatloaf made from ground meat with herbs mixed in, placed on a sheet of foil with crinkled edges. The meatloaf has a hollowed-out center that is fully filled with creamy, pale yellow macaroni and cheese, with curved elbow pasta pieces sitting on top in a slightly uneven layer. In the background, there is a clear glass bowl containing more macaroni and cheese. The setting is on a white marbled surface. photo taken with an iphone --ar 4:5 --v 7

The magic of this Macaroni and Cheese Stuffed Meatloaf Recipe starts with simple but essential ingredients, each carefully selected to build layers of flavor, texture, and a perfect balance between savory and sweet. You’ll find that each addition plays its part, from the tender ground beef to the creamy macaroni and cheese center.

1 ¼ lb. lean ground beef: Provides the juicy and tender meatloaf base without too much fat.

1 cup Italian seasoned breadcrumbs: Adds texture and helps bind the meatloaf together.
2 large eggs: Act as a natural binder to hold everything cohesively.
½ cup finely diced onion: Gives a gentle crunch and a mild sweet flavor that uplifts the meat.

2 teaspoon garlic powder: Infuses savory depth without overpowering the dish.
2 teaspoon dried parsley: Adds a fresh, herbaceous note and color contrast.
1 teaspoon salt: Enhances all the natural flavors in the meat mixture.

1 teaspoon black pepper: Brings a subtle kick and warmth.
½ cup honey BBQ sauce: Sweet and tangy, it adds moisture and a smoky undertone.
1 cup Bob Evans Macaroni and Cheese: The creamy, cheesy star for the stuffed center.

1 cup shredded mozzarella cheese: Melts beautifully to make the center extra gooey.
⅓ cup ketchup: Base for the classic meatloaf glaze that finishes the dish perfectly.
2 tablespoon brown sugar: Adds a caramelized sweetness to balance the tangy ketchup.

1 ½ tablespoon yellow mustard: Gives a sharp, savory zing to the glaze.

How to Make Macaroni and Cheese Stuffed Meatloaf Recipe

Step 1: Prepare Your Oven and Pan

Preheat your oven to 350 degrees Fahrenheit. Line a baking sheet with tinfoil and lightly spray it with non-stick spray. This step ensures an easy cleanup and prevents any delicious drippings from sticking to your pan as your meatloaf bakes to perfection.

Step 2: Combine the Meat Mixture

In a large bowl, mix together the lean ground beef, Italian seasoned breadcrumbs, eggs, finely diced onion, garlic powder, dried parsley, salt, black pepper, and honey BBQ sauce. Knead gently with your hands or a spatula until everything is fully incorporated but don’t overwork the meat—it helps keep the meatloaf tender and juicy.

Step 3: Shape the Meatloaf Base

Take half of the meat mixture and shape it into an 8-inch by 4-inch loaf right in the center of your lined baking sheet. Press down gently to create a small cavity in the middle, making sure to leave the sides about 1 inch thick so you can hold the cheesy filling in without leakage.

Step 4: Add the Macaroni and Cheese Filling

Mix the Bob Evans macaroni and cheese with the shredded mozzarella cheese in a separate bowl until nicely combined. Then, spoon this cheesy mixture right into the cavity of the meatloaf base. Now use the remaining meat mixture to cover the filling entirely, pinching the edges tightly closed to seal in all that gooey cheesy goodness.

Step 5: Bake Low and Slow

Bake the stuffed meatloaf for 40 minutes at 350 degrees Fahrenheit. This slower bake ensures the meat cooks thoroughly while setting perfectly around the cheesy center.

Step 6: Prepare and Apply the Glaze

While the meatloaf bakes, combine ketchup, brown sugar, and yellow mustard in a small dish to create your sweet and tangy glaze. After 40 minutes, carefully remove the meatloaf from the oven, increase the temperature to 400 degrees Fahrenheit, then brush this glaze generously over the top.

Step 7: Final Bake and Rest

Pop the glazed meatloaf back into the oven for an additional 10 to 15 minutes until the topping is bubbly and caramelized, and the meatloaf is cooked through. Once done, let the meatloaf rest for 5 to 10 minutes before slicing—this step locks in moisture and helps when cutting perfect slices that reveal that gorgeous macaroni and cheese center.

How to Serve Macaroni and Cheese Stuffed Meatloaf Recipe

A cooked meatloaf sits on a foil-lined surface with a white marbled texture underneath, showing a rough dark brown outer layer with white bits of onion visible throughout; melted cheese is oozing out from the meatloaf’s sides near the bottom. On top, a smooth, thick layer of reddish-brown sauce is being spread by a red silicone brush held by a woman's hand. In the background, there is a clear glass bowl containing more of the same sauce, slightly out of focus. Photo taken with an iphone --ar 4:5 --v 7

Garnishes

Start by sprinkling some freshly chopped parsley or chives over the sliced meatloaf to add a pop of color and a mild herbal note that complements the richness beautifully. A little cracked black pepper on top right before serving enhances the savory flavor and adds a touch of elegance to each piece.

Side Dishes

This hearty Macaroni and Cheese Stuffed Meatloaf Recipe pairs wonderfully with simple sides. Think buttery mashed potatoes, roasted green beans, or a crisp garden salad for a refreshing counterpoint. The creamy filling means your sides can be light and fresh or classic comfort food staples for maximum satisfaction.

Creative Ways to Present

Looking to impress at your next dinner? Try serving the meatloaf sliced thick with a drizzle of extra BBQ or glaze on the plate, surrounded by colorful roasted vegetables. For a fun twist, cut into individual mini-loaves or meatloaf muffins stuffed with macaroni and cheese—perfect for parties or kids’ meals!

Make Ahead and Storage

Storing Leftovers

Leftover Macaroni and Cheese Stuffed Meatloaf Recipe is delicious reheated and keeps well in an airtight container in the refrigerator for up to 3 days. Make sure to wrap slices tightly to maintain the moisture and prevent the cheesy center from drying out.

Freezing

You can freeze the entire meatloaf or sliced portions by wrapping them securely in plastic wrap and then aluminum foil, or using freezer-safe containers. It will stay fresh for up to 3 months. Thaw overnight in the refrigerator before reheating.

Reheating

When ready to enjoy leftovers, reheat in a 350-degree oven for about 15 to 20 minutes covered with foil to keep the moisture locked in. Avoid microwaving if possible, as the cheese center benefits from gentle, even reheating to stay creamy and melty.

FAQs

Can I use a different type of cheese in the filling?

Absolutely! While mozzarella and macaroni and cheese make a fantastic combo, feel free to experiment with cheddar, gouda, or even pepper jack for a little kick—just make sure the cheese melts well to keep that creamy texture.

Is it necessary to seal the edges tightly?

Yes, sealing the edges is key to keeping the macaroni and cheese filling inside during baking. If the filling leaks out, you lose that wonderful surprise center and it can make a mess on your baking sheet.

Can this recipe be made with ground turkey or chicken?

You can substitute ground beef with ground turkey or chicken for a leaner option, but be aware the meatloaf may be less juicy. Adding a bit more BBQ sauce or a splash of broth can help maintain moisture.

How do I know when the meatloaf is fully cooked?

The meatloaf should reach an internal temperature of 160 degrees Fahrenheit. If you don’t have a thermometer, ensure the juices run clear when you cut into it, and the meat feels firm but not dry.

Can I make the macaroni and cheese from scratch?

Definitely! Using homemade macaroni and cheese makes this dish even more special. Just make sure it’s thick enough so it won’t run or leak during baking. Let it cool before stuffing inside the meatloaf for best results.

Final Thoughts

This Macaroni and Cheese Stuffed Meatloaf Recipe is a heartwarming twist on two classic comfort dishes that will quickly become a family favorite. It’s straightforward enough for a weeknight, yet special enough to bring out when you want to wow your loved ones. Give it a try—you might just discover your new go-to weekend dinner that everyone talks about long after the last slice is gone.

Macaroni and Cheese Stuffed Meatloaf Recipe

Ingredients You'll Need